Sep 16, 2019 · Prior to start of synthesis, the injection valve was set to LOAD position (Figure 1) and a solution of aryl halide, palladium-source, supporting ligand and nucleophile in anhydrous solvent, was injected using a 1 mL syringe capped with a filter (Acrodisc 13 mm minispike with 0.45 μm GHP Membrane, Sigma-Aldrich, Sweden) through the injection