I have pulled more septa out of autosampler trays than I care to count, and the failure almost always looks the same: a neat circle of silicone sitting on top of the vial, a needle with a plug of rubber jammed in its bore, and a run that either aborted or, worse, injected a partial volume and reported a beautiful peak. Coring is the quiet killer of analytical sequences. It does not throw an error. It just changes your numbers. Over the years I have traced failed system suitability runs, out...